SpringerOpen Newsletter

Receive periodic news and updates relating to SpringerOpen.

Open Access Highly Accessed Research

Computational Convergence of the Path Integral for Real Dendritic Morphologies

Quentin Caudron12*, Simon R Donnelly3, Samuel PC Brand14 and Yulia Timofeeva12

Author Affiliations

1 Centre for Complexity Science, University of Warwick, Coventry, CV4 7AL, UK

2 Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK

3 Doctoral Training Centre in Neuroinformatics and Computational Neuroscience, University of Edinburgh, Edinburgh, EH8 9AB, UK

4 Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK

For all author emails, please log on.

The Journal of Mathematical Neuroscience 2012, 2:11  doi:10.1186/2190-8567-2-11

Published: 22 November 2012

Abstract

Neurons are characterised by a morphological structure unique amongst biological cells, the core of which is the dendritic tree. The vast number of dendritic geometries, combined with heterogeneous properties of the cell membrane, continue to challenge scientists in predicting neuronal input-output relationships, even in the case of sub-threshold dendritic currents. The Green’s function obtained for a given dendritic geometry provides this functional relationship for passive or quasi-active dendrites and can be constructed by a sum-over-trips approach based on a path integral formalism. In this paper, we introduce a number of efficient algorithms for realisation of the sum-over-trips framework and investigate the convergence of these algorithms on different dendritic geometries. We demonstrate that the convergence of the trip sampling methods strongly depends on dendritic morphology as well as the biophysical properties of the cell membrane. For real morphologies, the number of trips to guarantee a small convergence error might become very large and strongly affect computational efficiency. As an alternative, we introduce a highly-efficient matrix method which can be applied to arbitrary branching structures.

Keywords:
Dendrites; Path integral; Sum-over-trips; Morphology; Dendritic computation